Name: Epitalon 10mg
Brand: RetaLABS.is
SKU: epitalon-10mg

Question 1

What is Epitalon used for in research?

Accepted Answer

Epitalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide derived from epithalamin (a polypeptide extract produced by the pineal gland originally studied by researchers at the St. Petersburg Institute of Bioregulation and Gerontology. Epitalon is primarily researched for its effects on telomere biology and telomerase enzyme activity. Telomerase (telomerase reverse transcriptase; TERT) is an enzyme that adds repetitive nucleotide sequences to the ends of chromosomes, counteracting the progressive telomere shortening that occurs with each cell division. In preclinical models, Epitalon has been shown to activate telomerase in somatic cells and to increase average telomere length in aged organisms) effects studied in the context of cellular ageing and senescence research. Beyond telomere biology, Epitalon has been investigated for circadian rhythm modulation as a peptide bioregulator of the pineal-hypothalamic axis, antioxidant activity, and life-extension outcomes in rodent longevity models.

Question 2

How does Epitalon relate to telomerase research?

Accepted Answer

Telomerase is the ribonucleoprotein enzyme responsible for maintaining telomere length in stem cells, germ cells, and most cancer cells. In normal somatic (differentiated) cells, telomerase expression is typically suppressed, leading to progressive telomere erosion with each cell cycle, a molecular clock mechanism proposed to underlie replicative senescence and contribute to ageing phenotypes. Epitalon's relevance to telomerase research lies in its proposed ability to upregulate TERT (telomerase reverse transcriptase) expression in cells that normally lack telomerase activity. Preclinical studies have documented increases in telomerase activity in lymphocytes and other somatic cell types following Epitalon administration, alongside measurable increases in telomere length in treated animals compared to untreated controls. These findings position Epitalon as a research tool for studying the regulation of telomerase gene expression and the downstream consequences of telomere lengthening on cellular lifespan and chromosomal stability.

Question 3

How should Epitalon be stored?

Accepted Answer

Lyophilised Epitalon should be stored at −20°C, protected from light and moisture, to ensure maximum long-term stability. As a small synthetic tetrapeptide (Ala-Glu-Asp-Gly, molecular weight approximately 390 Da), Epitalon has good inherent stability in the lyophilised state (its simple unbranched sequence without disulfide bonds or particularly sensitive residues (no methionine, cysteine, or tryptophan) means it is less prone to the aggregation and oxidative degradation pathways that affect larger or more sensitive peptides. Vials should remain sealed and frozen until ready for use. To reconstitute, inject bacteriostatic water or sterile saline slowly along the inner vial wall and gently swirl until dissolved) the tetrapeptide dissolves rapidly. Once reconstituted, refrigerate at 2–8°C and use within four weeks. Avoid repeated freeze-thaw cycles of the reconstituted solution. For extended research programmes, keep the bulk lyophilised frozen and reconstitute fresh working aliquots periodically.

Question 4

What is the pineal gland connection in Epitalon research?

Accepted Answer

Epitalon's origins lie in pineal gland biology research conducted at the St. Petersburg Institute of Bioregulation and Gerontology, where Vladimir Khavinson and colleagues isolated epithalamin, a natural polypeptide complex secreted by the pineal gland, and identified the tetrapeptide sequence Ala-Glu-Asp-Gly as a bioactive component. The pineal gland is the neuroendocrine structure responsible for melatonin biosynthesis and is considered a regulator of circadian rhythm, seasonal adaptation, and neuroendocrine ageing. Pineal function declines with age, and the age-related reduction in pineal output has been proposed as a contributing factor in age-associated circadian disruption and immune dysregulation. Epitalon is studied as a synthetic peptide bioregulator of the pineal-hypothalamic axis, research has investigated its effects on melatonin secretion rhythms, circadian gene expression, and the neuroendocrine consequences of restoring pineal-like signalling in aged rodent models, providing context for its broader study in longevity and ageing biology.

Epitalon 10mg

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