Name: MOTS-c 40mg
Brand: RetaLABS.is
SKU: mots-c-40mg

Question 1

Why choose MOTS-c 40mg over the 10mg vial?

Accepted Answer

The 40mg vial offers a substantially lower cost per milligram, making it the preferred option for extended research protocols, multi-cohort studies, or researchers who need a consistent supply from a single batch to ensure experimental uniformity. Batch-to-batch consistency is particularly important for longitudinal research: if your protocol involves comparing early-phase and late-phase results, using material from the same production batch eliminates the analytical noise of potential minor inter-batch differences in purity. The larger vial also reduces logistical overhead, fewer individual vials to track, fewer reconstitution events per research period, and reduced risk of running short mid-protocol. For researchers who have completed pilot work with the 10mg format and are scaling to a full study, transitioning to the 40mg vial provides the same research-grade compound in a format optimised for programmatic scale. The reconstitution protocol, storage requirements, and quality specifications are identical across both formats.

Question 2

What is MOTS-c used for in research?

Accepted Answer

MOTS-c is a 16-amino-acid mitochondria-derived peptide researched for its role in metabolic regulation, insulin sensitivity, AMPK pathway activation, and adaptation to exercise-related metabolic stress. Encoded within the mitochondrial 12S rRNA gene, MOTS-c is one of the best-characterised members of the emerging class of mitochondria-derived peptides (MDPs) (peptides that serve as retrograde signals from mitochondria to the cytoplasm and nucleus. Metabolic research has demonstrated MOTS-c's ability to improve glucose homeostasis in rodent models of high-fat diet-induced and age-related insulin resistance, with AMPK activation identified as a central upstream mediator. Exercise biology research has documented increases in circulating MOTS-c during physical activity, and exogenous administration has been shown to partially replicate metabolic adaptations associated with aerobic training. Longevity research is investigating MOTS-c's role as an age-regulated mitochondrial signal, with plasma levels declining with age in human cohort studies) suggesting a link between MOTS-c and age-associated metabolic decline.

Question 3

How should MOTS-c 40mg be stored?

Accepted Answer

Store lyophilised MOTS-c 40mg vials at −20°C, protected from light and moisture. For extended protocols, the most important practice is to keep the bulk lyophilised and frozen throughout the research period (only reconstituting the volume needed for the immediate research session). This minimises the total number of reconstituted aliquots in circulation at any given time and reduces aggregate exposure of the compound to degradation conditions. When you need to prepare a working solution, draw bacteriostatic water and reconstitute only the portion required; store this at 2–8°C for up to four weeks. Do not store the reconstituted solution past this window. Discard and reconstitute a fresh aliquot from the frozen lyophilised stock. If your protocol spans many weeks, consider preparing multiple small aliquots from a single reconstitution event, freezing them at −20°C, and thawing one at a time rather than continuously using a single refrigerated vial.

Question 4

Is there a difference in potency between the 10mg and 40mg formats?

Accepted Answer

No, both the 10mg and 40mg formats are sourced from the same manufacturer and produced under identical synthesis and quality control conditions. The 40mg vial contains the same MOTS-c compound at the same research-grade purity standard; the only difference is the quantity per vial. Researchers sometimes ask this question because bulk formats in some industries use lower-grade starting material or relaxed quality standards compared to smaller premium formats, this is not the case here. Both formats undergo the same purity verification and are released under identical quality specifications. For research purposes, the analytical performance, AMPK activation potency and metabolic response in cell culture and animal models, will be indistinguishable between material sourced from the 10mg versus 40mg vial, provided both are handled and reconstituted under the same conditions. Choose the format based on research volume needs, not quality expectations.

MOTS-c 40mg

Customer Reviews

Frequently Asked Questions